Publications

Targeted-Neuroinflammation Mitigation Using Inflammasome-Inhibiting Nanoligomers is Therapeutic in an Experimental Autoimmune Encephalomyelitis Mouse Model.

Sadhana Sharma, Sydney Risen, Vincenzo S. Gilberto, Sean Boland, Anushree Chatterjee, Julie A. Moreno, and, Prashant Nagpal* (2024). ACS Chemical Neuroscience 15, 7, 1596–1608.

Large- and Small-Animal Studies of Safety, Pharmacokinetics, and Biodistribution of Inflammasome-Targeting Nanoligomer in the Brain and Other Target Organs.

Sydney Risen, Breonna Kusick, Sadhana Sharma, Vincenzo S. Gilberto, Stephen Brindley, Mikayla Aguilar, Jared M. Brown, Anushree Chatterjee, Julie A. Moreno*, and Prashant Nagpal* (2024). ACS Pharmacology and Translational Science (In press).

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Targeting Neuroinflammation by Pharmacologic Downregulation of Inflammatory Pathways Is Neuroprotective in Protein Misfolding Disorders.

Sydney J. Risen, Sean W. Boland, Sadhana Sharma, Grace M. Weisman, Payton M. Shirley, Amanda S. Latham, Arielle J. D. Hay, Vincenzo S. Gilberto, Amelia D. Hines, Stephen Brindley, Jared M. Brown, Stephanie McGrath, Anushree Chatterjee, Prashant Nagpal, and, Julie A. Moreno* (2024). ACS Chemical Neuroscience 15, 7, 1533-1547.

Nanoligomers targeting NF-κB and NLRP3 reduce neuroinflammation and improve cognitive function with aging and tauopathy.

Devin Wahl, Sydney J. Risen, Shelby C. Osburn, Tobias Emge, Sadhana Sharma, Vincenzo S. Gilberto, Anushree Chatterjee, Prashant Nagpal, Julie A. Moreno, Thomas J. LaRocca* (2024). BioRxiv.

Inflammasome-Inhibiting Nanoligomers are Neuroprotective Against Space-Induced Pathology in Healthy and Diseased 3D Human Motor and Pre-Frontal Cortex Brain Organoids.

Sadhana Sharma, Vincenzo S. Gilberto, Jon Rask, Anushree Chatterjee*, Prashant Nagpal* (2024). BioRxiv.

Identifying an Optimal Neuroinflammation Treatment Using a Nanoligomer Discovery Engine.

Sadhana Sharma, Curtis Borski, Jessica Hanson, Micklaus A. Garcia, Christopher D. Link, Charles Hoeffer, Anushree Chatterjee, and ,Prashant Nagpal* (2022). ACS Chemical Neuroscience 2022, 13, 23, 3247–3256.

NF-κB/NLRP3 Translational Inhibition by Nanoligomer Therapy Mitigates Ethanol and Advanced Age-Related Neuroinflammation.

Paige E. Anton, Prashant Nagpal, Julie Moreno, Matthew A. Burchill, Anushree Chatterjee, Nicolas Busquet, Michael Mesches, Elizabeth J. Kovacs, and Rebecca L. McCullough* (2024). BioRxiv.

Nanoligomers targeting human miRNA for treatment of severe COVID-19 are safe and nontoxic in mice.

Colleen R. McCollum, Colleen Courtney, Nolan O'Connor, Thomas Aunins, Yuchen Ding, Tristan Jordan, Keegan Rogers, Stephen Brindley, Jared Brown, Prashant Nagpal, and, Anushree Chatterjee* (2022). ACS Biomaterials Science and Engineering 8(7) 3087-3106.

Safety and biodistribution of NanoligomersTM targeting SARS-CoV-2 genome for treatment of COVID-19.

Colleen R. McCollum, Colleen M Courtney, Nolan J O'Connor, Thomas R Aunins, Tristan X Jordan, Keegan Rogers, Stephen Brindley, Jared M Brown, Prashant Nagpal, Anushree Chatterjee* (2023). ACS Biomaterials Science and Engineering 9(3):1656-1671.

Reversing Radiation-Induced Immunosuppression Using a New Therapeutic Modality

Colleen M Courtney, Sadhana Sharma, Christina Fallgren, Michael M Weil, Anushree Chatterjee, Prashant Nagpal* (2022). Life Sciences in Space Research, 35, 127-39.

Brain-Penetrant NF-κB and NLRP3 Targeting Nanoligomers are Therapeutic in Amyotrophic Lateral Sclerosis (ALS) and Alzheimer’s Disease (AD) Human Organoid and Mouse Models.

Sadhana Sharma, Devin Wahl, Sydney Risen, Vincenzo S. Gilberto, Anushree Chatterjee, Julie A. Moreno, Thomas J. LaRocca, Prashant Nagpal* (2024). BioRxiv.