Sachi Bio wins NASA SBIR Phase II award


Publications and press releases

SELECTED PUBLICATIONS BY SACHI TEAM
Safety and biodistribution of NanoligomersTM targeting SARS-CoV-2 genome for treatment of COVID-19.
Colleen Rei McCollum, Colleen M Courtney, Nolan J O'Connor, Thomas R Aunins, Tristan X Jordan, Keegan Rogers, Stephen Brindley, Jared M Brown, Prashant Nagpal, Anushree Chatterjee* (2023). ACS Biomaterials Science and Engineering 9(3):1656-1671.
Identifying an Optimal Neuroinflammation Treatment Using a Nanoligomer Discovery Engine
Sadhana Sharma, Curtis Borski, Jessica Hanson, Micklaus A. Garcia, Christopher D. Link, Charles Hoeffer, Anushree Chatterjee, and ,Prashant Nagpal* (2022) ACS Chem. Neurosci. 2022, 13, 23, 3247–3256.
Nanoligomers targeting human miRNA for treatment of severe COVID-19 are safe and nontoxic in mice.
Colleen McCollum, Colleen Courtney, Nolan O'Connor, Thomas Aunins, Yuchen Ding, Tristan Jordan, Keegan Rogers, Stephen Brindley, Jared Brown, Prashant Nagpal, and, Anushree Chatterjee* (2022). ACS Biomaterials Science and Engineering 8(7) 3087-3106.
Reversing Radiation-Induced Immunosuppression Using a New Therapeutic Modality
Colleen M Courtney, Sadhana Sharma, Christina Fallgren, Michael M Weil, Anushree Chatterjee, Prashant Nagpal* (2022). Life Sciences in Space Research, 35, 127-39.
Role of miR-2392 in driving SARS-CoV-2 infection.
J. Tyson McDonald, Francisco J. Enguita, Deanne Taylor, Robert J. Griffin, Waldemar Priebe, Mark R. Emmett, Mohammad M. Sajadi, Anthony D. Harris, Jean Clement, Joseph M.Dybas, Nukhet Aykin-Burns, Joseph W. Guarnieri, Larry N.Singh, Peter Grabham, Stephen B. Baylin, Aliza Yousey, Andrea N. Pearson, Peter M. Corry, Amanda Saravia-Butler, Thomas R. Aunins, Sadhana Sharma, Prashant Nagpal, Cem Meydan, Jonathan Foox, Christopher Mozsary, Bianca Cerqueira, Viktorija Zaksas, Urminder Singh, Eve Syrkin Wurtele, Sylvain V. Costes, Diego Galeano, Alberto Paccanaro, Suzanne L. Meinig, Robert S. Hagan, Natalie M.Bowman, UNC COVID-19 Pathobiology Consortium, Matthew C. Wolfgang, Selin Altinok, Nicolae Sapoval, Todd J. Treangen, Pedro M. Moraes-Vieira, Charles Vanderburg, Douglas C. Wallace, Jonathan C. Schisler, Christopher E. Mason, Anushree Chatterjee, Robert Meller, and Afshin Beheshti* (2021). Cell Reports. Volume 37, Issue 3, 19 October 2021, 109839.
Potentiating antibiotic treatment using fitness-neutral gene expression perturbations.
Peter B. Otoupal#, Kristen A. Eller#, Keesha E. Erickson, Jocelyn K. Campos, Thomas R. Aunins, Anushree Chatterjee* (2021). Nature Communications Biology 4 (1267).
Kristen A. Eller, Thomas R. Aunins, Colleen M. Courtney, Jocelyn K. Campos, Peter B. Otoupal, Keesha E. Erickson, Nancy E. Madinger, and Anushree Chatterjee* (2021). Nature Communications Biology 4:331.
Photoactivated indium phosphide quantum dots treat multi-drug resistant bacterial abscesses in vivo.
Colleen R. McCollum, John R. Bertram, Prashant Nagpal, and Anushree Chatterjee* (2021). ACS Applied Materials & Interfaces 13(26), 30404–30419.
Yonghui Ding, Richard Johnson, Sadhana Sharma, Xiaoyun Ding, Stephanie J Bryant and Wei Tan* (2020). Acta Biomateralia 105 , 68-77.
Transcriptome-based design of antisense inhibitors potentiates carbapenem efficacy in CRE E. coli.
Thomas R. Aunins, Keesha E. Erickson, Anushree Chatterjee* (2020). Proceedings of the National Academy of Sciences 117(48) 30699-30709.
Bertram J.R., Ding Y., Nagpal P* (2020). Nanoscale Advances, 2, 2363-2370.
Gary R. Abel, Lee E. Korshoj, Peter B. Otoupal, Sajida A. Khan, Anushree Chatterjee, and Prashant Nagpal* (2019). Chemical Sciences- Royal Society of Chemistry 10, 1052-1063.
Co-doping metal oxide nanotubes: Superlinear photoresponse and multianalyte sensing.
Saleh I.K., Ding Y., Nagpal P.* (2019). Materials Research Express, 6, 1150b1.
Near-infrared light triggered antimicrobial indium phosphide quantum dots
Levy M., Bertram J.R., Eller, K.A., Chatterjee A., Nagpal P.* (2019). Angewandte Chemie International Edition, 58, 11414.
Diagnostic optical sequencing.
Korshoj L.E., Nagpal P.* (2019). ACS Applied Materials and Interfaces, 11, 35587.
Aunins T.R., Eller K.A., Courtney C.M., Levy M., Goodman S.M., Nagpal P., Chatterjee A.* (2019). ACS Biomaterials Science and Engineering, 5, 4206.
Photophysical color tuning for photon upconverting nanoparticles.
Sun Q.-C., Ding Y., Nagpal P.* (2019). ACS Applied Materials and Interfaces, 11, 27011.
Ding Y., Bertram J.R., Eckert C., Bommareddy R.R., Patel R., Conradie A., Bryan S., Nagpal P.* (2019), Journal of the American Chemical Society, 141, 10272.
BOCS: DNA k-mer content and scoring for rapid genetic biomarker identification at low coverage.
Korshoj L.E., Nagpal P.* (2019). Computers in Biology and Medicine, 110, 196.
Levy M., Chowdhury P.P., Eller, K.A., Chatterjee A., Nagpal P.* (2019), ACS Biomaterials Science and Engineering, 5, 3111.
Quantum dot therapeutics: a new class of radical therapies.
Levy M., Chowdhury P.P., Nagpal P.*(2019). Journal of Biological Engineering, 13:48.
Otoupal P.B., Cordell W.T., Bachu V., Sitton M.J., and Chatterjee A.* (2018). Nature Communications Biology 1:129.
Thomas R. Aunins, Keesha E. Erickson, Nripesh Prasad, Shawn E. Levy, Angela Jones, Shristi Shrestha, Rick Mastracchio, Louis Stodieck, David Klaus, Luis Zea*, Anushree Chatterjee* (2018). Frontiers in Microbiology 9:310.
Biomimetic soft fibrous hydrogels for contractile and pharmacologically responsive smooth muscle.
Yonghui Ding, Xin Xu, Sadhana Sharma, Michael Floren, Kurt R Stenmark, Stephanie J Bryant, Corey P. Neu and Wei Tan* (2018). Acta Biomateralia 74 121-130.
Dharmesh Patel, Sadhana Sharma, Hazel RC Screen and Stephanie J Bryant* (2018). Biochem Biophys Res Commun 499(3), 642-647.
Sadhana Sharma, Michael Floren, Yonghui Ding, Kurt R Stenmark, Wei Tan and Stephanie J Bryant* (2017). Biomaterials 143 17-28.
Erickson K.E., Otoupal P.B., and Chatterjee A.*(2017). mSphere 2:e00009-17.
Lee E. Korshoj, Sepideh Afsari, Anushree Chatterjee, Prashant Nagpal* (2017). The Journal of American Chemical Society 139 (43), pp 15420–15428.
High-throughput block optical DNA sequence identification.
Sagar D.M., Korshoj L.E., Hanson K., Chowdhury P.P., Otoupal P., Chatterjee A., Nagpal P.* (2018) Small , 14, 1703165.
Quantum point contact single-nucleotide conductance for DNA and RNA sequence identification
Afsari S., Korshoj L.E., Abel G.A., Khan S.K., Chatterjee A., Nagpal P.* (2017) ACS Nano , 11, 11169.
Single nucleobase identification using biophysical signatures from nanoelectronic quantum tunneling
Korshoj L.E., Afsari S., Khan S., Chatterjee A.*, Nagpal P.* (2017). Small, 13, 1603033.
Split-Wedge Antennas with Sub-5 nm Gaps for Plasmonic Nanofocusing
Chen X., Lindquist N.C., Klemme D.J., Nagpal P., Norris D.J., Oh S.H.* (2016), Nano Letters, 16, 7849.
Photoexcited Quantum Dots for Killing Multi-Drug Resistant Bacteria.
Colleen M. Courtney#, Samuel Goodman#, Jessica Mc Daniel, Nancy Madinger, Anushree Chatterjee*, and Prashant Nagpal* (2016). Nature Materials 15, 529-534.
Sequence-specific peptide nucleic acid based antisense inhibitors of TEM-1 beta-lactamase and mechanism of adaptive resistance.
Courtney C.M., and Chatterjee A.* (2015). ACS Infectious Diseases 1 (6), pp 253–263.
Multiple Energy Exciton Shelves in Quantum Dot-DNA Nano-Bioelectronics.
Goodman S.M., Singh V., Ribot J.C., Chatterjee A., Nagpal P* (2014).The Journal of Physical Chemistry Letters, 5,3909.
Hyuk J., Nagpal P., McPeak K.M., Lindquist N., Oh S.H., Norris D.J.* (2013). ACS Applied Materials & Interfaces, 5, 9701.
Potentiating clinical drug resistant bacteria via stimuli-activated superoxide generation
Colleen M. Courtney, Samuel Goodman, Toni Nagy, Max Levy, Pallavi Bhusal, Nancy E. Madinger, Corrella Detweiler, Prashant Nagpal*, and Anushree Chatterjee* (2017). Science Advances 3:e1701776.
Anthony Doung, Sadhana Sharma, Kevin Peine, Gaurav Gupta, Abhay Satoskar, Eric Bachelder, Barbara Wyslouzil and Kristy M. Ainslie* (2013). Mol Pharm 10(3), 1045-55.
Kevin Schully, Sadhana Sharma, John T. Pesce, Andrea M. Keane-Myers, Eric Bachelder and Kristy M. Ainslie (2013). Pharma Res 30(5) , 1349-1361.
Antagonistic self-sensing and mate-sensing signaling controls antibiotic-resistance transfer.
Anushree Chatterjee#, Laura C. Cook#, Che-Chi Shu, Yuching Chen, Dawn Manias, Doraiswami Ramkrishna, Gary M. Dunny and Wei-Shou Hu* (2013). Proceedings of National Academy of Sciences, 110(17), 7086-7090.
Sadhana Sharma, Naveen Kanthamneni, Samantha A. Meenach, Beau Billet, Ji.-C. Zhao, Eric Bachelder and Kristy M. Ainslie (2012). Int J Pharm 431(1-2) , 101-110.
Im H., Lee S.H., Wittenberg, N.J., Johnson T.W., Lindquist N., Nagpal P., Norris D.J., Oh S.H.* (2011). ACS Nano, 5, 6244,
Convergent transcription confers a bistable switch in Enterococcus faecalis conjugation.
Anushree Chatterjee, Christopher M. Johnson, Che-Chi Shu, Yiannis N. Kaznessis, Doraiswami Ramkrishna, Gary M. Dunny and Wei-Shou Hu* (2011). Proceedings of the National Academy of Sciences, 108: 9721-9726
Role of mid-gap states in charge transport and photoconductivity in semiconductor nanocrystal films
Nagpal P., Klimov V.I.* (2011). Nature Communications, 2:486.
Fabrication of carbon/refractory metal nanocomposites as thermally stable metallic photonic crystals
Nagpal P., Josephson D.P., Denny N.R., DeWilde J., Norris D.J., Stein A.* (2011), Journal of Materials Chemistry, 21, 10836.
Nano-enabled Platforms for metastatic malignant melanoma.
Sadhana Sharma, John Shapiro, Robbie J. Walczak, and Piyush M. Sinha (2011). In Nanotechnology for Tissue Engineering and Regenerative Medicine, Ketul Popat (Editor) CRC Press, Taylor & Francis Group LLC, 6:1-34.
Matthew W. Curtis, Sadhana Sharma, Tejal A. Desai, and Brenda Russell* (2010) . Biomed Microdev 12 1073-1085.
High throughput assembly of spatially controlled 3D cell clusters on a micro/nano platform.
Sadhana Sharma, Daniel Gallego-Perez, Natalia Higuita-Castro, Rashmeet K. Reen, Andre F. Palmer, Keith J. Gooch, L. James Lee, John J. Lannutti and Derek J. Hansford* (2010). Lab on a chip 10 775-782.
Ultra-smooth patterned metals for Plasmonics and Metamaterials
Nagpal P., Lindquist N., Oh S.H., Norris D.J.* (2009). Science, 325, 594.
Efficient low temperature thermophotovoltaic emitters from metallic photonic crystals
Nagpal P., Han S.E., Stein A., Norris D.J.* (2008). Nano Letters, 8, 3238.
Quantitative XPS Analysis of PEG-Modified Silicon Surfaces
Ketul C. Popat, Sadhana Sharma, and Tejal A. Desai* (2004). J. Phys. Chem. B 2004, 108, 17, 5185–5188.
Controlled release microchips.
Sadhana Sharma, A. Jasper Nijdam, Piyush M. Sinha, Robbie J. Walczak, X. Liu, M.C.Cheng and Mauro Ferrari* (2006). Expert Opinion on Drug Delivery 3(3) 1-16.
Release of biologically functional interferon-alpha from a nanochannel delivery system.
Sadhana Sharma, Gregory B. Lesinski, Kimberly Varker, Piyush Sinha, Mauro Ferrari and William E. Carson* (2005). Biomed. Microdevices 7(1) 71-79.
Long-term biocompatibility of NanoGATE Drug Delivery Implant
Robbie J. Walczak, Anthony Boiarski, Michael Cohen, Teri West, Kristie Melnik, John Shapiro, Sadhana Sharma, and Mauro Ferrari* (2005) Nanobiotechnology 1(1) 35-42.
Sadhana Sharma, Robert W Johnson and Tejal A Desai* (2004). Langmuir 20(2) , 348-356.
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