Anushree Chatterjee, Ph. D.

co-founder, Chairperson, CEO

Mission: Making antisense therapeutics and precision medicine an accessible treatment option for patients to treat diseases.

My Story

Dr. Anushree Chatterjee has 15+ years of experience in synthetic and systems biology. She is the co-inventor of Sachi's drug discovery technology. She received her Bachelors and Masters of Technology in Chemical Engineering from Indian Institute of Technology Delhi in 2006. She earned her Ph.D. in Chemical engineering at the University of Minnesota on understanding molecular mechanisms of antibiotic resistance transfer in clinical superbugs in 2011. She was a postdoctoral research fellow at the Theoretical Biology and Biophysics group at Los Alamos National Laboratory studying gene regulation of hepatitis C virus till 2012. In 2013, Anushree joined the faculty at University of Colorado Boulder. She has published 75+ papers in high-impact peer-reviewed journals, given over 80 invited talks, and 100+ contributed talks. Anushree has received numerous awards including the National Academy of Medicine’s Healthy Longevity Award, DARPA Young Faculty Award, ACS Infectious Diseases Young Investigator Award, New Inventor of the Year award, Provost’s Faculty Achievement award, and the prestigious William M. keck Foundation grant award. Anushree’s research has been featured by academic and federal institutions such as the Material Research Society, Faculty of 1000, and the National Science Foundation, as well as popular national and international media outlets including BBC, CGTN America, and Voice of America. She has also founded/co-founded two Biotech startup companies, the non-profit organization Antimicrobial Regeneration Consortium Labs. Until the end of 2023 she was an Associate Professor of Chemical and Biological Engineering at University of Colorado Boulder. Building on a successful academic career, starting 2024 Dr. Chatterjee has dedicated full-time at Sachi Bio towards commercialization and deployment of Nanoligomers in the clinical setting.

PUBLICATIONS WITH NANOLIGOMERS

Targeted-Neuroinflammation Mitigation Using Inflammasome-Inhibiting Nanoligomers is Therapeutic in an Experimental Autoimmune Encephalomyelitis Mouse Model.

Sadhana Sharma, Sydney Risen, Vincenzo S. Gilberto, Sean Boland, Anushree Chatterjee, Julie A. Moreno, and, Prashant Nagpal* (2024). ACS Chemical Neuroscience 15, 7, 1596–1608.

Large- and Small-Animal Studies of Safety, Pharmacokinetics, and Biodistribution of Inflammasome-Targeting Nanoligomer in the Brain and Other Target Organs.

Sydney Risen, Breonna Kusick, Sadhana Sharma, Vincenzo S. Gilberto, Stephen Brindley, Mikayla Aguilar, Jared M. Brown, Stephanie McGrath, Anushree Chatterjee, Julie A. Moreno*, and Prashant Nagpal* (2024). ACS Pharmacol.ogy and Translational Science (In press).

Targeting Neuroinflammation by Pharmacologic Downregulation of Inflammatory Pathways Is Neuroprotective in Protein Misfolding Disorders.

Sydney J. Risen, Sean W. Boland, Sadhana Sharma, Grace M. Weisman, Payton M. Shirley, Amanda S. Latham, Arielle J. D. Hay, Vincenzo S. Gilberto, Amelia D. Hines, Stephen Brindley, Jared M. Brown, Stephanie McGrath, Anushree Chatterjee, Prashant Nagpal, and, Julie A. Moreno* (2024). ACS Chemical Neuroscience 15, 7, 1533-1547.

Inflammasome-Inhibiting Nanoligomers are Neuroprotective Against Space-Induced Pathology in Healthy and Diseased 3D Human Motor and Pre-Frontal Cortex Brain Organoids.

Sadhana Sharma, Vincenzo S. Gilberto, Jon Rask, Anushree Chatterjee*, Prashant Nagpal* (2024). BioRxiv.

Brain-Penetrant NF-κB and NLRP3 Targeting Nanoligomers are Therapeutic in Amyotrophic Lateral Sclerosis (ALS) and Alzheimer’s Disease (AD) Human Organoid and Mouse Models.

Sadhana Sharma, Devin Wahl, Sydney Risen, Vincenzo S. Gilberto, Anushree Chatterjee, Julie A. Moreno, Thomas J. LaRocca, Prashant Nagpal* (2024). BioRxiv.

Nanoligomers targeting NF-κB and NLRP3 reduce neuroinflammation and improve cognitive function with aging and tauopathy.

Devin Wahl, Sydney J. Risen, Shelby C. Osburn, Tobias Emge, Sadhana Sharma, Vincenzo S. Gilberto, Anushree Chatterjee, Prashant Nagpal, Julie A. Moreno, Thomas J. LaRocca* (2024). BioRxiv.

NF-κB/NLRP3 Translational Inhibition by Nanoligomer Therapy Mitigates Ethanol and Advanced Age-Related Neuroinflammation.

Paige E. Anton, Prashant Nagpal, Julie Moreno, Matthew A. Burchill, Anushree Chatterjee, Nicolas Busquet, Michael Mesches, Elizabeth J. Kovacs, and Rebecca L. McCullough* (2024). BioRxiv.

Microbiome- and Host Inflammasome-Targeting Inhibitor Nanoliogmers are Therapeutic in Murine Colitis Model.

Sadhana Sharma, Vincenzo S. Gilberto, Cassandra L. Levens, Anushree Chatterjee, Kristine A. Kuhn, Prashant Nagpal* (2024). BioRxiv.

Safety and biodistribution of NanoligomersTM targeting SARS-CoV-2 genome for treatment of COVID-19.

Colleen R. McCollum, Colleen M Courtney, Nolan J O'Connor, Thomas R Aunins, Tristan X Jordan, Keegan Rogers, Stephen Brindley, Jared M Brown, Prashant Nagpal, Anushree Chatterjee* (2023). ACS Biomaterials Science and Engineering 9(3):1656-1671.

Identifying an Optimal Neuroinflammation Treatment Using a Nanoligomer Discovery Engine.

Sadhana Sharma, Curtis Borski, Jessica Hanson, Micklaus A. Garcia, Christopher D. Link, Charles Hoeffer, Anushree Chatterjee, and ,Prashant Nagpal* (2022). ACS Chemical Neuroscience 2022, 13, 23, 3247–3256.

Nanoligomers targeting human miRNA for treatment of severe COVID-19 are safe and nontoxic in mice.

Colleen R. McCollum, Colleen Courtney, Nolan O'Connor, Thomas Aunins, Yuchen Ding, Tristan Jordan, Keegan Rogers, Stephen Brindley, Jared Brown, Prashant Nagpal, and, Anushree Chatterjee* (2022). ACS Biomaterials Science and Engineering 8(7) 3087-3106.

Reversing Radiation-Induced Immunosuppression Using a New Therapeutic Modality

Colleen M Courtney, Sadhana Sharma, Christina Fallgren, Michael M Weil, Anushree Chatterjee, Prashant Nagpal* (2022). Life Sciences in Space Research, 35, 127-39.

Looking on the horizon; potential and unique approaches to developing radiation countermeasures for deep space travel.

Rihana S Bokhari, Afshin Beheshti, Sarah E Blutt, Dawn E Bowles, David Brenner, Robert Britton, Lawrence Bronk, Xu Cao, Anushree Chatterjee, Delisa E Clay, Colleen Courtney, Donald T Fox, M Waleed Gaber, Sharon Gerecht, Peter Grabham, David Grosshans, Fada Guan, Erin A Jezuit, David G Kirsch, Zhandong Liu, Mirjana Maletic-Savatic, Kyle M Miller, Ruth A Montague, Prashant Nagpal, Sivan Osenberg, Luke Parkitny, Niles A Pierce, Christopher Porada, Susan M Rosenberg, Paul Sargunas, Sadhana Sharma, Jamie Spangler, Daniel Naveed Tavakol, Dilip Thomas, Gordana Vunjak-Novakovic, Chunbo Wang, Luke Whitcomb, Damian W Young, Dorit Donoviel* (2022). Life Sciences in Space Research (35) 105-112.

Role of miR-2392 in driving SARS-CoV-2 infection.

J. Tyson McDonald, Francisco J. Enguita, Deanne Taylor, Robert J. Griffin, Waldemar Priebe, Mark R. Emmett, Mohammad M. Sajadi, Anthony D. Harris, Jean Clement, Joseph M.Dybas, Nukhet Aykin-Burns, Joseph W. Guarnieri, Larry N.Singh, Peter Grabham, Stephen B. Baylin, Aliza Yousey, Andrea N. Pearson, Peter M. Corry, Amanda Saravia-Butler, Thomas R. Aunins, Sadhana Sharma, Prashant Nagpal, Cem Meydan, Jonathan Foox, Christopher Mozsary, Bianca Cerqueira, Viktorija Zaksas, Urminder Singh, Eve Syrkin Wurtele, Sylvain V. Costes, Diego Galeano, Alberto Paccanaro, Suzanne L. Meinig, Robert S. Hagan, Natalie M.Bowman, UNC COVID-19 Pathobiology Consortium, Matthew C. Wolfgang, Selin Altinok, Nicolae Sapoval, Todd J. Treangen, Pedro M. Moraes-Vieira, Charles Vanderburg, Douglas C. Wallace, Jonathan C. Schisler, Christopher E. Mason, Anushree Chatterjee, Robert Meller, and Afshin Beheshti* (2021). Cell Reports. Volume 37, Issue 3, 19 October 2021, 109839.

OTHER SELECTED PUBLICATIONS

For complete publication list: Go to Pubmed or Google Scholar

Modeling Ionizing Radiation-induced Cardiovascular Dysfunction with Human iPSC-Derived Engineered Heart Tissues.

Xu Cao, Dilip Thomas, Luke Whitcomb, Mingqiang Wang, Anushree Chatterjee, Adam J Chicco, Michael M Weil, Joseph C Wu* (2024). Journal of molecular and cellular cardiology (188) 105.

A high-throughput and low-waste viability assay for microbes.

Christian T. Meyer*, Grace K. Lynch, Dana F. Stamo, Eugene J Miller, Anushree Chatterjee*, Joel M Kralj* (2023). Nature Microbiology (8), 2304–2314.

Potentiating antibiotic treatment using fitness-neutral gene expression perturbations.

Peter B. Otoupal#, Kristen A. Eller#, Keesha E. Erickson, Jocelyn K. Campos, Thomas R. Aunins, Anushree Chatterjee* (2021). Nature Communications Biology 4 (1267).

Facile accelerated speciﬁc therapeutic (FAST) platform develops antisense therapies to counter multidrug-resistant bacteria.

Kristen A. Eller, Thomas R. Aunins, Colleen M. Courtney, Jocelyn K. Campos, Peter B. Otoupal, Keesha E. Erickson, Nancy E. Madinger, and Anushree Chatterjee* (2021). Nature Communications Biology 4:331.

Photoactivated indium phosphide quantum dots treat multi-drug resistant bacterial abscesses in vivo.

Colleen R. McCollum, John R. Bertram, Prashant Nagpal, and Anushree Chatterjee* (2021). ACS Applied Materials & Interfaces 13(26), 30404–30419.

Transcriptome-based design of antisense inhibitors potentiates carbapenem efficacy in CRE E. coli.

Thomas R. Aunins, Keesha E. Erickson, Anushree Chatterjee* (2020). Proceedings of the National Academy of Sciences 117(48) 30699-30709.

Near-infrared light triggered antimicrobial indium phosphide quantum dots

Levy M., Bertram J.R., Eller, K.A., Chatterjee A., Nagpal P.* (2019). Angewandte Chemie International Edition, 58, 11414.

Multiplexed deactivated CRISPR-Cas9 gene expression perturbations deter bacterial adaptation by inducing negative epistasis.

Otoupal P.B., Cordell W.T., Bachu V., Sitton M.J., and Chatterjee A.* (2018). Nature Communications Biology 1:129.

Potentiating clinical drug resistant bacteria via stimuli-activated superoxide generation

Colleen M. Courtney, Samuel Goodman, Toni Nagy, Max Levy, Pallavi Bhusal, Nancy E. Madinger, Corrella Detweiler, Prashant Nagpal*, and Anushree Chatterjee* (2017). Science Advances 3:e1701776.

Photoexcited Quantum Dots for Killing Multi-Drug Resistant Bacteria.

Colleen M. Courtney#, Samuel Goodman#, Jessica Mc Daniel, Nancy Madinger, Anushree Chatterjee*, and Prashant Nagpal* (2016). Nature Materials 15, 529-534.

Antagonistic self-sensing and mate-sensing signaling controls antibiotic-resistance transfer.

Anushree Chatterjee#, Laura C. Cook#, Che-Chi Shu, Yuching Chen, Dawn Manias, Doraiswami Ramkrishna, Gary M. Dunny and Wei-Shou Hu* (2013). Proceedings of National Academy of Sciences, 110(17), 7086-7090.

Convergent transcription confers a bistable switch in Enterococcus faecalis conjugation.

Anushree Chatterjee, Christopher M. Johnson, Che-Chi Shu, Yiannis N. Kaznessis, Doraiswami Ramkrishna, Gary M. Dunny and Wei-Shou Hu* (2011). Proceedings of the National Academy of Sciences, 108: 9721-9726.

Ph: 720-361-2159

info@sachibio.com

3000 Airport Drive, Unit 201,

Erie, CO 80516

Anushree Chatterjee, Ph. D.

My Story

OTHER SELECTED PUBLICATIONS

For complete publication list: Go to Pubmed or Google Scholar

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