Prashant Nagpal -2.JPG

Prashant Nagpal, Ph. D.

co-founder, CTO, COO

Mission: Making medicines programmable and bringing solutions to market, to impact lives.

My Story

Dr. Prashant Nagpal has more than 15 years of experience in nanoscience and nanotechnology, quantum biology, molecular spectroscopy, and physical chemistry.  He is the co-inventor Sachi's drug discovery technology. Prashant received his B.S. from Indian Institute of Technology Delhi in 2004, and earned his Ph.D. from University of Minnesota in 2009. After working for 2.5 years at Los Alamos National Laboratory as a post-doctoral scholar, he joined the University of Colorado Boulder in August 2012.

Prashant's research has been published in more than 60 publications in peer reviewed, high-impact journals such as Science, Nature Materials, Nature Communications, Physical Review Letters, Nano Letters, JACS, ACS Nano, Angewandte Chemie, and he has filed and granted more than 20 patents based on his work, given over 50 invited talks, and has received numerous awards and honors including the New Inventor of the Year Award (2013), NSF CAREER Award (2014), Keck Foundation Research Award (2015), Outstanding Junior Faculty Award by University of Colorado (2017), and more recently, Emerging Leader in Biological Engineering (2019) award. His work has been highlighted in more than 100 national and international print and media outlets, and was recently featured in ABC Evening News, France 24, BBC, Newsweek, MSN, Times of India, R&D Magazine, Outlook, Indian Express, Huffington Post, Popular Mechanics, Daily Mail, The Statesman, and KGNU’s Science show “How on Earth”. He has also founded two Biotech startup companies, and the non-profit organization Antimicrobial Regeneration Consortium Labs.

Publications

61. “Reversing radiation-induced immunosuppression using a new therapeutic modality”,

Courtney C.M., Sharma S., Fallgren C., Weil M.M., Chatterjee A., Nagpal P.*, Life Sciences in Space Research, DOI: 10.1016/j.lssr.2022.05.002 (2021).

 

60. “Role of miR-2392 in driving SARS-CoV-2 infection”,

McDonald J.T., …, Nagpal P.,…., Beheshti A.*, Cell Reports, 37 (3), 109839 (2021).

 

59. “Photoactivated Indium Phosphide quantum dots treat multidrug-resistant bacterial abscesses in vivo”,

McCollum C.R., Bertram J.R., Nagpal P., Chatterjee A.*, ACS Applied Materials and Interfaces, 13 (26), 30404 (2021).

 

58. “Light-activated quantum dot potentiation of antibiotics to treat drug-resistant bacterial biofilms”,

Stamo D.F., Nagpal P., Chatterjee A.*, Nanoscale Advances, 3 (10), 2782 (2021).

 

57. “Photoexcited quantum dots as efficacious and nontoxic antibiotics in an animal model”,

McCollum C.R.., Levy M., Bertram J.R., Nagpal P., Chatterjee A.*, ACS Biomaterials Science and Engineering, 7 (5), 1863 (2021).

 

56. “Gold nanoclusters cause selective light-driven biochemical catalysis in living nano-biohybrid organisms”,

Bertram J.R., Ding Y., Nagpal P.*, Nanoscale Advances, 2, 2363 (2020).

 

55. “Analysis of Identification Method for Bacterial Species and Antibiotic Resistance Genes using Optical Data from DNA Oligomers”,

Wood R.L., Jensen T., Wadsworth C., Clement M., Nagpal P., Pitt W.G., Frontiers in Microbiology, 11:257 (2020).

 

54. “Co-doping metal oxide nanotubes: Superlinear photoresponse and multianalyte sensing”,

Saleh I.K., Ding Y., Nagpal P.*, Materials Research Express, 6, 1150b1 (2019).

 

53. “Diagnostic optical sequencing”,

Korshoj L.E., Nagpal P.*, ACS Applied Materials and Interfaces, 11, 35587 (2019).

 

52. “Isolating the Escherichia coli transcriptomic response to superoxide generation from cadmium chalcogenide quantum dots”,

Aunins T.R., Eller K.A., Courtney C.M., Levy M., Goodman S.M., Nagpal P., Chatterjee A.*, ACS Biomaterials Science and Engineering, 5, 4206 (2019).

 

51. “Photophysical color tuning for photon upconverting nanoparticles”,

Sun Q.-C., Ding Y., Nagpal P.*, ACS Applied Materials and Interfaces, 11, 27011 (2019).

 

50. “Near-infrared light triggered antimicrobial indium phosphide quantum dots”,

Levy M., Bertram J.R., Eller, K.A., Chatterjee A., Nagpal P.*, Angewandte Chemie International Edition, 58, 11414 (2019).

 

49. “Nanorg microbial factories: Light-driven renewable biochemical synthesis using quantum dot-bacteria nano-biohybrids”,

Ding Y., Bertram J.R., Eckert C., Bommareddy R.R., Patel R., Conradie A., Bryan S., Nagpal P.*, Journal of the American Chemical Society, 141, 10271 (2019).

 

Invention highlighted by: University of Colorado Press Release, Colorado Public Radio, R&D Magazine , Science Daily, Danielle Smith Show

 

Press: Phys.Org, EurekAlert,  Financial Express , Green Car Congress , Business Standard, Sky News, Scientific Russia, Rinnovabili, Iranian News Agency, Yahoo News, Firstpost , InnovatioNews, WessexFM, NanoWerk, BioEngineer, ScienceCodex, GreatDriffieldRadio, PandaRadio, EagleRadio, EasternMirror, Nature World News, RT, Devdiscourse, HansIndia, C2W, Pressetext, Haberler, Trustmyscience, WNP,  The Week, Photonics, Science Daily, News Nation, Louisville Reports, World Energy Trade, iwradio, Europlat,  Osel, Shweizer Morgenpost, R&D Magazine, Domain-b, AzoNano, Futura Sciences, Enviro2B, Sonnenseite, Inovacao Tecnologica, Outlook India, ChemInfo, Daily Geek Show,  Die Welt, Colorado Public Radio, Indian Express, Forschung und Wissen,  Digital Journal, Design News

 

48. “BOCS: DNA k-mer content and scoring for rapid genetic biomarker identification at low coverage”,

Korshoj L.E., Nagpal P.*, Computers in Biology and Medicine, 110, 196 (2019).

 

47. “Tuning ternary Zn1-xCdxTe quantum dot composition: Engineering electronic states for light-activated superoxide generation as a therapeutic against multidrug-resistant bacteria”,

Levy M., Chowdhury P.P., Eller K.A., Chatterjee A., Nagpal P.*, ACS Biomaterials Science and Engineering, 5, 3111 (2019).

 

46. “Quantum dot therapeutics: a new class of radical therapies”,

Levy M., Chowdhury P.P., Nagpal P.*, Journal of Biological Engineering, 13:48 (2019).

Invited Review as an “Emerging Leader in Biological Engineering”

 

45. “Nucleotide and structural label identification in single RNA molecules with quantum tunneling spectroscopy”,

Abel G.A., Korshoj L.E., Otoupal P.B., Khan S. K., Chatterjee A., Nagpal P.*, Chemical Science, 10, 1052 (2019).

 

44. “Assessing different reactive oxygen species as potential antibiotics: Selectivity of intracellular superoxide generation using quantum dots”,

Levy M., Courtney C.M., Chowdhury P.P., Ding Y., Grey E.L., Goodman S.M., Chatterjee A., Nagpal P.*, ACS Applied BioMaterials, 1, 529 (2018).

 

43. “Designing superoxide-generating quantum dots for selective light-activated nanotherapy”,

Goodman S.M., Levy M., Li F.F., Ding Y., Courtney C.M., Chowdhury P.P., Erbse A., Chatterjee A., Nagpal P.*, Frontiers in Chemistry, 6, 46 (2018).  Invited Article

 

42. “High-throughput block optical DNA sequence identification”,

Sagar D.M., Korshoj L.E., Hanson K.B., Chowdhury P.P., Otoupal P.B., Chatterjee A., Nagpal P.*, Small, 14, 1703165 (2018). 

 

Invention highlighted by: University of Colorado Press Release

 

Press: Phys.Org, Health Unlocked, Global News Connect, Buffzone, NewsWise, Health & Medicine News, Science Daily

 

41. “Conformational smear characterization and binning of single-molecule conductance measurements for enhanced molecular recognition”,

Korshoj L.E., Afsari S., Chatterjee A., Nagpal P.*, Journal of the American Chemical Society, 139, 15420 (2017). 

 

Invention highlighted by: University of Colorado Press Release

 

Press: Phys.Org, Health Unlocked, Global News Connect, Buffzone, NewsWise, Health & Medicine News, Science Daily

 

40. “Quantum point contact single-nucleotide conductance for DNA and RNA sequence identification”,

Afsari S., Korshoj L.E., Abel G.R., Khan S., Chatterjee A., Nagpal P.*, ACS Nano, 11, 11169 (2017).

 

Invention highlighted by: University of Colorado Press Release

 

Press: Phys.Org, Health Unlocked, Global News Connect, Buffzone, NewsWise, Health & Medicine News, Science Daily

 

39. “Potentiating antibiotics in drug-resistant clinical isolates via stimuli-activated superoxide generation”,

Courtney C.M., Goodman C.M., Nagy T., Levy M., Madinger N., Detweiler C., Nagpal P.*, Chatterjee A.*, Science Advances, 3, e1701776 (2017). (Impact Factor: Not Available)

 

Newsweek, MSN, and BBC covered the discovery

 

Invention highlighted by: University of Colorado Press Release, Newsweek, MSN, International Business Times, BBC

 

Press: IEEE Spectrum, Phys.Org, EurekAlert, Science Daily, Nanowerk, AzoNano , Center for Infectious Disease Research and Policy, ResearchGate , AzoNano , NanotechWeb, Technology.Org, Science Alert, NewsWise , LongRoom, Drug Discovery and Development, Science News, News Medical

 

38. “Photon upconversion towards applications in energy conversion and bioimaging”,

Sun Q., Ding Y., Sagar D.M., Nagpal P.*, Progress in Surface Science, 92, 281, (2017). Invited Review

 

37. “ROS mediated selection for increased NADPH availability in Escherichia coli”,

Reynolds T.S., Courtney C.M., Erickson K.E., Wolfe L.M., Chatterjee A., Nagpal P., Gill R.T.*, Biotechnology and Bioengineering, 114, 2685 (2017).

 

36. “Titanium dioxide nanotube membranes for solar energy conversion: effect of deep and shallow dopants”,

Ding Y., Nagpal P.*, Physical Chemistry Chemical Physics, 19, 100423 (2017). (Impact Factor: 4.123)

 

35. “Single nucleobase identification using biophysical signatures from nanoelectronic quantum tunneling”,

Korshoj L.E., Afsari S., Khan S., Chatterjee A.*, Nagpal P.*, Small, 13, 1603033 (2017).

 

34. “Standalone anion- and co-doped titanium dioxide nanotubes for photocatalytic and photoelectrochemical solar-to-fuel conversion”,

Ding Y., Nagpal P.*, Nanoscale, 8, 17496 (2016).  

 

33. “Photoexcited quantum dots for killing multidrug-resistant bacteria”,

Courtney C.M., Goodman S.M., McDaniel J.A., Madinger N.E., Chatterjee A.*, Nagpal P.*, Nature Materials, 15, 529 (2016).  

 

ABC NEWS Denver Channel 7 Evening News, France 24, and Voice of America covered the discovery

 

 National Science Foundation News Highlight

 

Invention highlighted by: University of Colorado Press Release , Huffington Post , Daily Mail , Boston Global Media-Stat , Yahoo News , Popular Mechanics , Times of India , Zee News , Big News Network , France 24, Voice of America, ChBE Highlight

 

Press: Science Daily , EurekAlert , Science Alert , Phys Org , Genetic Engineering and Biotechnology News , Photonics.Com , Science Newsline , News Wise , News Headline Spot , e Science News , Tech News Now , WN.com , Quantum Times , Compound Semiconductor , Jersey Tribune , Controlled Environments , Infection Control Today , Scicasts , Nanotechnology Now , British Society of Nanomedicine , Nanowerk , Innovation Toronto , ZME Science , Inverse , ScienMag , The Medical News , Tech Times , Business Standard , IndiaNewEngland , GizMag , BGR , RT , Medical Daily

 

International News Coverage: Indian Media Times of India  Frontier Mail  World News 24X7 , Zee News , MedIndia , Insights on India , DaijiWorld , Canadian Media CanIndiaNews , British Media Daily Mail , Spanish Media Lainformacion  elEconomista.es  Quo.es , Australian Media Big News Network , Russian Media ACLP.ru , Armenian Media NEWS.am , German Media Trendsderzukunft

 

32. “Long range energy transfer in self-assembled quantum dot-DNA cascades”,

Goodman S.M., Siu A., Singh V., Nagpal P.*, Nanoscale, 7, 18435 (2015).  

 

31. “Air-gating and chemical-gating in transistors and sensing devices made from hollow TiO2 semiconductor nanotubes”,

Alivov Y., Funke H., Nagpal P.*, Nanotechnology, 26, 295203 (2015).

 

30. “Measurements of Single Nucleotide Electronic States as Nanoelectronic Fingerprints for Identification of DNA Nucleobases, Their Protonated and Unprotonated States, Isomers, and Tautomers”,

Ribot J.C., Chatterjee A.*, Nagpal P.*, The Journal of Physical Chemistry B, 119, 4968 (2015).

 

29. “Charge transport through exciton shelves in cadmium chalcogenide quantum dot-DNA nano-bioelectronic thin films”,

Goodman S.M., Noh H., Singh V., Cha J.N., Nagpal P.*, Applied Physics Letters, 106, 083109 (2015).

28. Air-pressure tunable depletion width, rectification behavior, and charge conduction in oxide nanotubes”,

Alivov Y., Hans H., Singh V., Nagpal P.*, ACS Applied Materials and Interfaces, 7, 2153 (2015).

 

27. “Titanium-dioxide homojunction p-n diode”,

Alivov Y., Ding Y., Singh V., Nagpal P.*, Applied Physics Letters, 105, 263501 (2014).

 

26. “Low exciton-phonon coupling, high charge carrier mobilities, and multiexciton properties in two-dimensional (2D) lead, cadmium, silver, and copper chalcogenide nanostructures”,

Ding Y., Singh V., Goodman S.M., , (2014).

 

25. “Multiple energy exciton shelves in quantum dot-DNA nano-bioelectronics”,

Goodman S., Singh V., Ribot J.C., Chatterjee A., Nagpal P.*, The Journal of Physical Chemistry Letters, 5, 3909 (2014).

 

24. “Pseudo-direct bandgap transitions in silicon nanocrystals: effect on optoelectronics and thermoelectrics”,

Singh V., Yu Y., Sun Q., Korgel B., Nagpal P.*, Nanoscale, 6, 14643 (2014).

 

23. “Copper plasmonics and catalysis: Role of electron-phonon interactions in dephasing localized surface plasmons ”,

Sun Q., Ding Y., Goodman S., Funke H., Nagpal P.*, Nanoscale, 6, 12450 (2014).

 

22. “Doping of Wide-Bandgap Semiconductor Nanotubes: Optical, Electronic and Magnetic Dopants”,

Alivov Y., Singh V., Ding Y., Cerkovnik L.J., Nagpal P.*, Nanoscale, 6, 10839 (2014).

 

21. “Transparent conducting oxide nanotubes”,

Alivov Y., Singh V., Ding Y., Nagpal P.*, Nanotechnology, 25, 385202 (2014).

 

Paper highlighted as Publishers Pick by Institute of Physics (IOP).

 

Paper selected as IOP Select (freely available for a year and included in a special collection of the highest quality work published across IOP journals).

 

Press: NanotechWeb from Institute of Physics, Tech Transfer Office Press Release.

 

20. “Effect of plasmon-enhancement on photophysics in  upconverting nanoparticles”,

        Sun Q., Ribot J.C., Singh V., Mundoor, H., Smalyukh I.I., Nagpal P.*, Optics Express, 22, 11516 (2014).

 

19. “Photocatalysis deconstructed: design of a new catalysts for artificial photosynthesis”,

Singh V., Beltran I.J.C., Ribot, J.C., Nagpal P.*, Nano Letters, 14, 597 (2014).

 

18. “Direct conjugation of DNA to quantum dots for scalable assembly of photoactive thin films”,

Noh H., Goodman S., Mohan P., Goodwin A.P., Nagpal P., Cha J.N.*, RSC Advances, 4, 8064 (2014).

 

17. “Plasmon-enhanced energy transfer for improved upconversion of infrared radiation in doped lanthanide nanocrystals”,

Sun Q., Mundoor, H., Ribot J.C., Singh V., Smalyukh I.I., Nagpal P.*, Nano Letters, 14, 101 (2014).

 

Paper highlighted in Nature Materials.

 

Press: Hispanic Business, Vertical News, Journal of Visualized Experiments (JoVE)

 

16. “Split-Wedge Antennas with Sub-5 nm Gaps for Plasmonic Nanofocusing”,

Chen X., Lindquist N.C., Klemme D.J., Nagpal P., Norris D.J., Oh S.H., Nano Letters, 16, 7849 (2016).  

 

15. “Observation of thermal beaming from tungsten and molybdenum bull’s eye”,

Park J.H., Han S.E., Nagpal P., Tischler J.G., Norris D.J., ACS Photonics, 3, 494 (2016).  

14. “Fabrication of Smooth Patterned Structures of Refractory Metals, Semiconductors, and Oxides via Template Stripping”,

Hyuk J., Nagpal P., McPeak K.M., Lindquist N., Oh S.H., Norris D.J., ACS Applied Materials & Interfaces, 5, 9701 (2013).

 

13. “Plasmonic nanofocusing with a metallic pyramid and an integrated C-shaped aperture”,

Lindquist N., Johnson T.W., Nagpal P., Norris D.J., Oh S.H., Scientific Reports, 3, 1857, (2013).

 

12. “Measurement of electronic states of PbS nanocrystal quantum dots using scanning tunneling spectroscopy: The role of parity selection rules in optical absorption”,

Diaconescu B., Padilha L.A., Nagpal P., Swartzentruber B.S.., Klimov V.I, Physical Review Letters, 110, 127406, (2013).

 

11. “Single-Crystalline silver films for plasmonics”,

 Hyuk J., Ambwani P., Manno M., Lindquist N., Nagpal P., Oh S.H., Leighton C., Norris D.J., Advanced Materials, 24, 3988, (2012).

 

10. “Improved dielectric function in metallic films obtained via template stripping”,

 Hyuk J., Nagpal P., Oh S.H., Norris D.J., Applied Physics Letters, 100, 081105, (2012).

 

9. “Engineering metallic nanostructures for plasmonic and nanophotonics”,

Lindquist N., Nagpal P., McPeak K., Norris D.J., Oh S.H., Reports on Progress in Physics, 75, 036501, (2012).

 

8. “Role of mid-gap states in charge transport and photoconductivity in semiconductor nanocrystal films”,

 Nagpal P., Klimov V.I., Nature Communications, 2:486 , (2011).

 

7. “Spectral dependence of nanocrystal photoionization probability: The role of hot-carrier transfer”,

Padilha L.A., Robel I., Lee D.C., Nagpal P., Pietryga J.M., Klimov V.I., ACS Nano, 5, 5045, (2011).

 

6. “Template-stripped smooth Ag nanohole arrays with silica shells for surface plasmon resonance biosensing”,

Im H., Lee S.H., Wittenberg, N.J., Johnson T.W., Lindquist N., Nagpal P., Norris D.J., Oh S.H., ACS Nano, 5, 6244, (2011).

 

Press: NanotechWeb from Institute of Physics.

 

5. “Fabrication of carbon/refractory metal nanocomposites as thermally stable metallic photonic crystals”,

Nagpal P., Josephson D.P., Denny N.R., DeWilde J., Norris D.J., Stein A., Journal of Materials Chemistry, 21, 10836, (2011).

 

4. “Three-dimensional Plasmonic Nanofocusing”,

 Lindquist N., Nagpal P., Norris D.J., Oh S.H., Nano Letters, 10, 1369, (2010).

 

3. “Ultra-smooth patterned metals for Plasmonics and Metamaterials”,

 Nagpal P., Lindquist N., Oh S.H., Norris D.J., Science, 325, 594, (2009).

 

Paper highlighted in Nature Photonics and Nature Nanotechnology.

 

Press: Discovery Channel, Technology Review, Physics World, Chemistry World.

 

2. “Efficient low temperature thermophotovoltaic emitters from metallic photonic crystals”, Nagpal P., Han S.E., Stein A., Norris D.J., Nano Letters, 8, 3238, (2008).

1. “Thermally stable organic-inorganic hybrid photoresists for fabrication of photonic band gap structures using direct laser writing”,

Jun Y., Nagpal P., Norris D.J., Advanced Materials, 20, 606, (2008).