Sadhana Sharma-1.jpg

Sadhana Sharma, Ph. D.

Director of Research and Development

Mission: Making tissue chips and personalized medicine a reality.

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My Story

Dr. Sadhana Sharma has 20+ years of experience in micro- and nano- technologies and biomaterials for developing nanomedicine, tissue engineered devices, and high throughput screening platforms for various biomedical applications.  She received her masters and Ph. D. in Bioseparations from the Indian Institute of Technology Delhi. She also received Ph.D. (Bioengineering) from the University of Illinois at Chicago (UIC) in 2002 where she developed nanostructured poly(ethylene glycol) thin films for microfabricated nanoporous controlled release chips for pharmaceutical delivery and immunoisolation applications. 

Sadhana has worked with various generations of controlled release platforms for cancer and cardiovascular applications and collaborated with startups further developing and commercializing this technology. She has also developed micro/ nanoparticulate or scaffold-based platforms for pharmaceutical, gene, and vaccine delivery for a variety of disease conditions. In addition, She has extensive experience in the development of photoclickable hydrogel-based 3-D high-throughput tissue mimetics for drug screening and disease modeling. She has authored over thirty-two research articles in peer-reviewed journals, nine book chapters / conference proceedings, presented over fifty-seven technical talks/posters, and has two patents issued to her name. Sadhana has received several awards throughout her career including Fellow of Ruth L. Kirschstein National Research Service Award. She also serves as a research faculty in Chemical and Biological Engineering at University of Colorado Boulder.

Selected Publications

  • Colleen M Courtney, Sadhana Sharma, Christina Fallgren, Michael M Weil, Anushree Chatterjee, Prashant Nagpal* (2022). Reversing Radiation-Induced Immunosuppression Using a New Therapeutic Modality. Life Sciences in Space Research (In press).

  • A photoclickable peptide microarray platform for facile and rapid screening of 3-D tissue microenvironments. Sadhana Sharma, Michael Floren, Yonghui Ding, Kurt R Stenmark, Wei Tan and Stephanie J Bryant* (2017). Biomaterials 143 17-28.

  • Biomimetic soft fibrous hydrogels for contractile and pharmacologically responsive smooth muscle.Yonghui Ding, Xin Xu, Sadhana Sharma, Michael Floren, Kurt R Stenmark, Stephanie J Bryant, Corey P. Neu and Wei Tan* (2018). Acta Biomateralia 74 121-130.

  • Tethering transforming growth factor β1 to soft hydrogels guides vascular smooth muscle commitment from human mesenchymal stem cells. Yonghui Ding, Richard Johnson, Sadhana Sharma, Xiaoyun Ding, Stephanie J Bryant and Wei Tan* (2020). Acta Biomateralia 105 , 68-7.