Sachi SB8.U.1_EPO and SB1.U.2_CSF2 safely boost host immune response

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Sachi Nanoligomer™ platform was utilized to test more than 17 immunomodulatory targets up- and down-, to identify best-in-class and first-in-class molecules SB8.U.1_EPO and SB1.U.2_CSF2 that can safely boost host immune system.(Ref. 1)

 

 

 

 

 

 

 

These molecules not only activate multilineage immune defense like their recombinant protein counterpart (GM-CSF Leukine),(Refs. 2–5) but unlike GM-CSF cytokine that activates only pro-inflammatory response and hence contraindicated in patients with known sensitivity to auto-immune diseases.  It activates anti-inflammatory cytokines, maintains balance of Th1/Th2/ and Th17 cells, and also shown to upregulate Treg cells, showing a balanced and true immune boost (not just pro-inflammatory) increasing it’s potential applicability as a prophylactic and therapeutic for a range of conditions from compromised immune system (e.g. patients undergoing chemotherapy and radiotherapy) to broad-spectrum pathogen-agnostic anti-infective (anti-viral,(Refs. 3,5–9) anti-fungal,(Refs. 2,10) anti-bacterial(Refs. 2,3,9–11))

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References

  1. Courtney, C. M. et al. Reversing Radiation-Induced Immunosuppression Using a New Therapeutic Modality. Life Sci. Sp. Res. (2022) doi:10.1016/j.lssr.2022.05.002.

  2. Armitage, J. O. Emerging applications of recombinant human granulocyte-macrophage colony-stimulating factor. Blood vol. 92 (1998).

  3. Petrina, M., Martin, J. & Basta, S. Granulocyte macrophage colony-stimulating factor has come of age: From a vaccine adjuvant to antiviral immunotherapy. Cytokine and Growth Factor Reviews vol. 59 (2021).

  4. Mellman, I. Dendritic cells: master regulators of the immune response. Cancer immunology research vol. 1 (2013).

  5. Unkel, B. et al. Alveolar epithelial cells orchestrate DC function in murine viral pneumonia. J. Clin. Invest. 122, (2012).

  6. Huang, F. F. et al. GM-CSF in the Lung Protects against Lethal Influenza Infection. Am. J. Respir. Crit. Care Med. 184, (2011).

  7. Subramaniam, R. et al. Delivery of GM-CSF to protect against influenza pneumonia. PLoS One 10, (2015).

  8. Schneider, C. et al. Alveolar Macrophages Are Essential for Protection from Respiratory Failure and Associated Morbidity following Influenza Virus Infection. PLoS Pathog. 10, (2014).

  9. Subramaniam, R. et al. Protecting against post-influenza bacterial pneumonia by increasing phagocyte recruitment and ROS production. J. Infect. Dis. 209, (2014).

  10. Damiani, G., McCormick, T. S., Leal, L. O. & Ghannoum, M. A. Recombinant human granulocyte macrophage-colony stimulating factor expressed in yeast (sargramostim): A potential ally to combat serious infections. Clinical Immunology vol. 210 (2020).

  11. Ghoneim, H. E., Thomas, P. G. & McCullers, J. A. Depletion of Alveolar Macrophages during Influenza Infection Facilitates Bacterial Superinfections. J. Immunol. 191, (2013).

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